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The US State Department issued a shelter-in-place warning for US citizens in the states of Jalisco, Tamaulipas, as well as some areas in Michoacan, Guerrero and Nuevo Leon.
She wrote on X that “in most parts of the country, activities are proceeding normally”.
Watch: Vehicles set ablaze across Mexico amid violence
El Mencho, a 59-year-old former police officer, ran a vast criminal organisation responsible for trafficking huge quantities of cocaine, methamphetamine and fentanyl into the US.
The Mexican defence ministry said in a statement that the operation was “planned and executed” by the country’s special forces.
Aircraft from the Mexican Air Force and the National Guard were also deployed.